Interleukin 6 modulates PPARα and PGC-1α and is involved in high-fat diet induced cardiac lipotoxicity in mouse.

@article{Bonda2016Interleukin6M,
  title={Interleukin 6 modulates PPARα and PGC-1α and is involved in high-fat diet induced cardiac lipotoxicity in mouse.},
  author={Tomasz Andrzej Bonda and Beata Szynaka and Magdalena Sokołowska and Magdalena Dziemidowicz and Ewa Monika Waszkiewicz and Maria Małgorzata Winnicka and Piotr S. Bernaczyk and Natalia Wawrusiewicz-Kurylonek and Karol Adam Kaminski},
  journal={International journal of cardiology},
  year={2016},
  volume={219},
  pages={1-8}
}
BACKGROUND Interleukin 6 (IL-6) may be involved in regulation of cardiac lipid metabolism and mitochondrial function through its influence on peroxisome proliferator-activated receptors (PPARs). In this study we evaluated the impact of the physiological level of IL-6 on the expression of PPARα and PGC-1α in the heart and the effect of lack of this cytokine on high-fat diet (HFD) induced lipotoxicity. METHODS Male C57BL6/J wild type (WT) and IL-6 knock-out (IL-6KO) mice were used. 20 animals… CONTINUE READING

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