Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.

@article{SchoenigerSkinner2007Interleukin6ML,
  title={Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.},
  author={Diana K Schoeniger-Skinner and Annemarie Ledeboer and Matthew G Frank and Erin D. Milligan and Stephen Poole and David Martin and Steven F. Maier and Linda R. Watkins},
  journal={Brain, behavior, and immunity},
  year={2007},
  volume={21 5},
  pages={660-7}
}
Spinal cord glia (microglia and astrocytes) contribute to enhanced pain states. One model that has been used to study this phenomenon is intrathecal (i.t.) administration of gp120, an envelope glycoprotein of HIV-1 known to activate spinal cord glia and thereby induce low-threshold mechanical allodynia, a pain symptom where normally innocuous (non-painful) stimuli are perceived as painful. Previous studies have shown that i.t. gp120-induced allodynia is mediated via the release of the glial pro… CONTINUE READING
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