Interleukin-6-mediated autocrine growth promotion in human glioblastoma multiforme cell line U87MG.

@article{Goswami1998Interleukin6mediatedAG,
  title={Interleukin-6-mediated autocrine growth promotion in human glioblastoma multiforme cell line U87MG.},
  author={Shyamal K Goswami and Anu Gupta and Sanjay Sharma},
  journal={Journal of neurochemistry},
  year={1998},
  volume={71 5},
  pages={1837-45}
}
Human glioblastoma multiforme cell lines, brain tumor biopsy tissue, and normal human fetal brain synthesize interleukin (IL)-6 and IL-6 receptor (IL-6R). Neither of these is expressed in human neurons or neuroblastoma cell lines in culture. Astrocytes from fetal brain grown in culture retain the ability to synthesize IL-6 but do not express IL-6R as inferred from RT-PCR and Southern blot studies. Coexpression of IL-6 and IL-6R in the glioblastoma cell line U87MG is confirmed by… CONTINUE READING