Interleukin-6 is necessary, but not sufficient, for induction of the humanC-reactive protein gene in vivo.

@article{Weinhold1997Interleukin6IN,
  title={Interleukin-6 is necessary, but not sufficient, for induction of the humanC-reactive protein gene in vivo.},
  author={Birgit Weinhold and Augustinus Bader and Valeria Poli and Ulrich U R{\"u}ther},
  journal={The Biochemical journal},
  year={1997},
  volume={325 ( Pt 3)},
  pages={617-21}
}
We have investigated the involvement of interleukin-6 (IL-6) in the induction of the gene encoding the acute-phase protein human C-reactive protein (hCRP). In transgenic mice the hCRP gene can be induced by lipopolysaccharide (LPS), but not by IL-6. In contrast, hCRP was inducible by IL-6 in primary human hepatocytes and in primary hepatocytes isolated from transgenic mice. To further evaluate the role of IL-6, we introduced the hCRP transgene into animals lacking endogenous IL-6 (IL-6-negative… CONTINUE READING

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