Interleukin-6 induction by Helicobacter pylori in human macrophages is dependent on phagocytosis.

@article{Odenbreit2006Interleukin6IB,
  title={Interleukin-6 induction by Helicobacter pylori in human macrophages is dependent on phagocytosis.},
  author={Stefan Odenbreit and Stefan Linder and Bettina Gebert-Vogl and Gabriele Rieder and Anthony P. Moran and Rainer Haas},
  journal={Helicobacter},
  year={2006},
  volume={11 3},
  pages={196-207}
}
BACKGROUND The colonization of the gastric mucosa with Helicobacter pylori is accompanied by elevated levels of proinflammatory cytokines, such as interleukin-1 (IL-1), IL-6, and IL-8. The aim of our study was to determine the mechanisms of IL-6 stimulation in phagocytes upon H. pylori infection. MATERIALS AND METHODS We investigated the secretion of IL-6 by different professional phagocytes from murine and human origin, including granulocyte- and monocyte-like cells and macrophages derived… CONTINUE READING

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