Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance

@inproceedings{Almuraikhy2016Interleukin6II,
  title={Interleukin-6 induces impairment in human subcutaneous adipogenesis in obesity-associated insulin resistance},
  author={Shamma Almuraikhy and Wael Kafienah and Moataz M. Bashah and Ilhame Diboun and Morana Jaganjac and Fatima Al-Khelaifi and Houari Boumediene Abdesselem and Nayef A. Mazloum and Mohammed Alsayrafi and Vidya Mohamed-Ali and Mohamed A Elrayess},
  booktitle={Diabetologia},
  year={2016}
}
A subset of obese individuals remains insulin sensitive by mechanisms as yet unclear. The hypothesis that maintenance of normal subcutaneous (SC) adipogenesis accounts, at least partially, for this protective phenotype and whether it can be abrogated by chronic exposure to IL-6 was investigated. Adipose tissue biopsies were collected from insulin-sensitive (IS) and insulin-resistant (IR) individuals undergoing weight-reduction surgery. Adipocyte size, pre-adipocyte proportion of stromal… CONTINUE READING