Interleukin 6 induces DNA binding activity of AP1 in M1 myeloblastic cells but not in a growth resistant cell derivative.

@article{Melamed1993Interleukin6I,
  title={Interleukin 6 induces DNA binding activity of AP1 in M1 myeloblastic cells but not in a growth resistant cell derivative.},
  author={Dan Melamed and Dalia Resnitzky and I Haimov and Nitzan Levy and Curt M Pfarr and M. Yaniv and Adi Kimchi},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1993},
  volume={4 8},
  pages={689-97}
}
The effects that three different growth inhibitory cytokines exert on expression and function of members of the Jun family were studied in this work. M1 myeloblastic cells were chosen for this purpose because of their high growth sensitivity to interleukin 6 (IL-6), transforming growth factor beta 1 and alpha- and beta-interferons. It is reported here that IL-6 elevated the junB and c-jun mRNA levels and induced the formation of a novel DNA-protein complex with high sequence specificity to 12-O… CONTINUE READING
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