Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3.

@article{Niehof2001Interleukin6inducedTO,
  title={Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3.},
  author={Monika Niehof and Konrad L. Streetz and T Rakemann and Stephan C. Bischoff and Michael P. Manns and Friedemann Horn and Francisco Javier Cubero},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 12},
  pages={9016-27}
}
LAP/C/EBPbeta is a member of the C/EBP family of transcription factors and contributes to the regulation of the acute phase response in hepatocytes. Here we show that IL-6 controls LAP/C/EBPbeta gene transcription and identify an IL-6 responsive element in the LAP/C/EBPbeta promoter, which contains no STAT3 DNA binding motif. However, luciferase reporter gene assays showed that STAT3 activation through the gp130 signal transducer molecule is involved in mediating IL-6-dependent LAP/C/EBPbeta… CONTINUE READING

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