Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury.

@article{Leu2001Interleukin6inducedSA,
  title={Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury.},
  author={Julia I-Ju Leu and Mary Ann S. Crissey and James P. Leu and G. Ciliberto and Rebecca Taub},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 2},
  pages={414-24}
}
Following hepatic injury or stress, gluconeogenic and acute-phase response genes are rapidly upregulated to restore metabolic homeostasis and limit tissue damage. Regulation of the liver-restricted insulin-like growth factor binding protein 1 (IGFBP-1) gene is dramatically altered by changes in the metabolic state and hepatectomy, and thus it provided an… CONTINUE READING