Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow.

@article{Ni2004Interleukin6inducedJS,
  title={Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow.},
  author={Chih-Wen Ni and Hsyue-Jen Hsieh and Y C Chao and Danny L Wang},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={287 3},
  pages={C771-80}
}
Endothelial cells (ECs) are constantly exposed to shear stress, the action of which triggers signaling pathways and cellular responses. During inflammation, cytokines such as IL-6 increase in plasma. In this study, we examined the effects of steady flow on IL-6-induced endothelial responses. ECs exposed to IL-6 exhibited STAT3 activation via phosphorylation of Tyr705. However, when ECs were subjected to shear stress, shear force-dependent suppression of IL-6-induced STAT3 phosphorylation was… CONTINUE READING

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A C779 HEMODYNAMIC FLOW SUPPRESSES IL-6-INDUCED SIGNALING PATHWAY AJP-Cell Physiol

  • R Starr, TA Willson, +8 authors DJ. Hilton
  • 2004
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