Interleukin-6 in rheumatoid arthritis

@article{Nishimoto2006Interleukin6IR,
  title={Interleukin-6 in rheumatoid arthritis},
  author={Norihiro Nishimoto},
  journal={Current Opinion in Rheumatology},
  year={2006},
  volume={18},
  pages={277–281}
}
  • N. Nishimoto
  • Published 1 May 2006
  • Medicine, Biology
  • Current Opinion in Rheumatology
Purpose of reviewRecent progress in cytokine studies has clarified the pathological roles played by cytokines and provided key evidence that antagonizing their actions can be therapeutic. The pathogenesis of rheumatoid arthritis, an autoimmune inflammatory disease, involves inflammatory cytokines such as tumour necrosis factor-α, interleukin-1 and interleukin-6. Anti-tumour necrosis factor-α and anti-interleukin-1 therapies have been used successfully to treat rheumatoid arthritis, but they are… 
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It is postulate that there is a specific niche for nonhuman primate models of inflammatory arthritis to address these systemic complications that occur in RA and these models in nonhuman primates can be valuable for studying disease-related aspects that cannot be addressed in rodent models.
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The results demonstrated that peripheral blood NK cells from healthy individuals have the ability to secrete IL-6 after co-culture with target cells against which these cells are known to exhibit direct cytotoxicity (either K562 or HeLa cells).
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Findings indicate that the expression pattern of immunohistochemical findings in synovium was changed in effect attenuation cases among RA patients treated with infliximab.
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