Interleukin-6 in rheumatoid arthritis
@article{Nishimoto2006Interleukin6IR, title={Interleukin-6 in rheumatoid arthritis}, author={N. Nishimoto}, journal={Current Opinion in Rheumatology}, year={2006}, volume={18}, pages={277–281} }
Purpose of reviewRecent progress in cytokine studies has clarified the pathological roles played by cytokines and provided key evidence that antagonizing their actions can be therapeutic. The pathogenesis of rheumatoid arthritis, an autoimmune inflammatory disease, involves inflammatory cytokines such as tumour necrosis factor-α, interleukin-1 and interleukin-6. Anti-tumour necrosis factor-α and anti-interleukin-1 therapies have been used successfully to treat rheumatoid arthritis, but they are… CONTINUE READING
Topics from this paper
180 Citations
Humanized antihuman IL-6 receptor antibody, tocilizumab.
- Medicine
- Handbook of experimental pharmacology
- 2008
- 133
Inflammatory pathways of importance for management of inflammatory bowel disease.
- Medicine
- World journal of gastroenterology
- 2014
- 102
Dissecting the contribution of B cells in an experimental model of rheumatoid arthritis
- Medicine
- 2014
- PDF
Tocilizumab for the treatment of rheumatoid arthritis
- Medicine
- Expert review of clinical immunology
- 2008
- 2
Sirukumab for the treatment of rheumatoid arthritis: update on sirukumab, 2018
- Medicine
- Expert review of clinical immunology
- 2018
- 3
New drug discovery strategies for rheumatoid arthritis: a niche for nonhuman primate models to address systemic complications in inflammatory arthritis
- Medicine
- Expert opinion on drug discovery
- 2012
- 3
PRO-INFLAMMATORY SIGNAL DELIVERED IN VITRO BY LEFLUNOMIDE ACTIVE METABOLITE A77 1726 ON ABNORMAL PERIPHERAL MONOCYTES IN RHEUMATOID ARTHRITIS
- Medicine
- 2010
- 3
- PDF
Histological analysis of synovium in cases of effect attenuation associated with infliximab therapy in rheumatoid arthritis
- Medicine
- Clinical Rheumatology
- 2008
- 14
References
SHOWING 1-10 OF 40 REFERENCES
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial.
- Medicine
- Arthritis and rheumatism
- 2004
- 747
Interleukin 6 Is Required for the Development of Collagen-induced Arthritis
- Medicine
- The Journal of experimental medicine
- 1998
- 599
- PDF
Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.
- Medicine
- The New England journal of medicine
- 2000
- 2,993
- PDF
Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides.
- Medicine
- Arthritis and rheumatism
- 1988
- 865
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.
- Medicine
- Arthritis and rheumatism
- 2003
- 316
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis.
- Medicine
- Arthritis and rheumatism
- 1998
- 272
Do We Need New Treatment That Goes beyond Tumor Necrosis Factor Blockers for Rheumatoid Arthritis?
- Medicine
- Annals of the New York Academy of Sciences
- 2005
- 38