Interleukin-6 in pregnancy and gestational disorders.

  title={Interleukin-6 in pregnancy and gestational disorders.},
  author={Jelmer R. Prins and Nardhy Gomez-Lopez and Sarah A Robertson},
  journal={Journal of reproductive immunology},
  volume={95 1-2},
IL6 is a multifunctional cytokine with pivotal roles in the inflammatory response and in directing T cell differentiation in adaptive immunity. IL6 is widely expressed in the female reproductive tract and gestational tissues, and exerts regulatory functions in embryo implantation and placental development, as well as the immune adaptations required to tolerate pregnancy. Here, we summarise the current understanding of how membrane-bound and soluble receptors mediate IL6 signalling to regulate… CONTINUE READING

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