Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target

@article{Tvedt2017Interleukin6IA,
  title={Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target},
  author={T. H. Tvedt and E. Ersvaer and A. Tveita and {\O}. Bruserud},
  journal={Frontiers in Immunology},
  year={2017},
  volume={8}
}
  • T. H. Tvedt, E. Ersvaer, +1 author Ø. Bruserud
  • Published 2017
  • Biology, Medicine
  • Frontiers in Immunology
  • Allogeneic stem cell transplantation is associated with a high risk of treatment-related mortality mainly caused by infections and graft-versus-host disease (GVHD). GVHD is characterized by severe immune dysregulation and impaired regeneration of different tissues, i.e., epithelial barriers and the liver. The balance between pro- and anti-inflammatory cytokine influences the risk of GVHD. Interleukin-6 (IL-6) is a cytokine that previously has been associated with pro-inflammatory effects… CONTINUE READING
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