Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.

@article{Porgador1992Interleukin6G,
  title={Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.},
  author={Angel Porgador and Esther Tzehoval and Adam W Katz and Ezra Vadai and M. Revel and Michael Feldman and Lea Eisenbach},
  journal={Cancer research},
  year={1992},
  volume={52 13},
  pages={3679-86}
}
To investigate the influence of interleukin 6 (IL-6) production on malignancy of tumor cells we transfected cells of the high-metastatic, low-immunogenic D122 clone of the Lewis lung carcinoma with a mammalian expression vector containing the human IL-6 complementary DNA. In vitro, IL-6 positive transfectants showed growth inhibition that was directly correlated with the levels of IL-6 production. The in vitro growth arrest did not seem to be a function of an autocrine system mediated via the… CONTINUE READING

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