Interleukin-6 family cytokine M17 induces differentiation and nitric oxide response of goldfish (Carassius auratus L.) macrophages.

@article{Hanington2007Interleukin6FC,
  title={Interleukin-6 family cytokine M17 induces differentiation and nitric oxide response of goldfish (Carassius auratus L.) macrophages.},
  author={Patrick C Hanington and Miodrag Mike Belosevic},
  journal={Developmental and comparative immunology},
  year={2007},
  volume={31 8},
  pages={817-29}
}
Cytokines belonging to the interleukin-6 (IL-6) family function in many biological processes and display a high degree of redundancy within the family. Although a number of mRNA transcripts from teleost fish that resemble IL-6 family cytokines have been identified none have been functionally characterized to confirm their identity. We report on the identification and functional characterization of goldfish M17, a molecule possessing sequence and mRNA expression patterns similar to the mammalian… CONTINUE READING

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