Interleukin-6 expression by interactions between gynecologic cancer cells and human mesenchymal stem cells promotes epithelial-mesenchymal transition.

@article{So2015Interleukin6EB,
  title={Interleukin-6 expression by interactions between gynecologic cancer cells and human mesenchymal stem cells promotes epithelial-mesenchymal transition.},
  author={Kyeong A So and Kyung-jin Min and Jin Hwa Hong and Jae Kwan Lee},
  journal={International journal of oncology},
  year={2015},
  volume={47 4},
  pages={1451-9}
}
Epithelial-to-mesenchymal transition (EMT) facilitates the invasion and metastasis of cancer cells. EMT seems to be mediated by the interaction between cancer cells and human mesenchymal stem cells (hMSCs) in the tumor microenvironment. The present study is intended to identify specific cytokines as potent inducers of EMT associated hMSCs-tumor interactions. We used ovarian cancer cell lines (SKOV-3 and IGROV-1), endometrial cancer cell line (Ishikawa) and hMSCs (bone marrow MSC, amniotic… CONTINUE READING
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Mesenchymal stem cells engineered for cancer therapy

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