Interleukin-6 enhances whereas tumor necrosis factor alpha and interferons inhibit integrin expression and adhesion of human mast cells to extracellular matrix proteins.

@article{Schoeler2003Interleukin6EW,
  title={Interleukin-6 enhances whereas tumor necrosis factor alpha and interferons inhibit integrin expression and adhesion of human mast cells to extracellular matrix proteins.},
  author={Dagmar Schoeler and Andreas Gr{\"u}tzkau and Beate Maria Henz and Jens K{\"u}chler and Sabine Krueger-Krasagakis},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={120 5},
  pages={795-801}
}
Integrins are expressed on mast cells and constitute an essential prerequisite for the accumulation of the cells at sites of inflammation. In order to clarify a potential contribution of inflammatory cytokines to this process, we have studied the modulation of integrin expression and adhesion of immature human mast cells (HMC-1) to extracellular matrix proteins by interleukin-6, tumor necrosis factor alpha, interferon-alpha and interferon-gamma. Corticosteroids were used for comparison. On… CONTINUE READING
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