Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

@article{Ellingsgaard2011Interleukin6EI,
  title={Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells},
  author={Helga Ellingsgaard and Irina Hauselmann and Beat Schuler and Abdella M. Habib and Laurie L. Baggio and Daniel T. Meier and Elisabeth Eppler and Karim Bouzakri and Stephan Wueest and Yannick D Muller and Ann Maria Kruse Hansen and Manfred Reinecke and Daniel Konrad and Max Gassmann and Frank Reimann and Philippe A. Halban and Jesper Gromada and Daniel J Drucker and Fiona Mary Gribble and Jan Adam Ehses and Marc Yves Donath},
  journal={Nature Medicine},
  year={2011},
  volume={17},
  pages={1481-1489}
}
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin secretion. Here we show that administration of IL-6 or elevated IL-6 concentrations in response to exercise stimulate GLP-1 secretion from intestinal L cells and pancreatic alpha cells, improving insulin secretion and glycemia. IL-6 increased GLP-1 production from alpha cells through increased proglucagon (which is… CONTINUE READING
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