Interleukin-6 does not mediate endotoxin-induced uveitis in mice: studies in gene deletion animals.

@article{Rosenbaum1998Interleukin6DN,
  title={Interleukin-6 does not mediate endotoxin-induced uveitis in mice: studies in gene deletion animals.},
  author={James T. Rosenbaum and Paul Kievit and Yibing Han and Jong Moon Park and Stephen R. Planck},
  journal={Investigative ophthalmology & visual science},
  year={1998},
  volume={39 1},
  pages={64-9}
}
PURPOSE Interleukin-6 (IL-6) has been strongly implicated in anterior uveitis based on its presence in aqueous humor from infected eyes and its inflammatory effects when injected intravitreally into rats. We used IL-6-deficient mice to test further the hypothesis that IL-6 contributes to the development of endotoxin-induced uveitis. METHODS Uveitis was scored by histologic analysis of C3H/HeN mice 24 hours after intravitreal injections of up to 200 ng of recombinant murine IL-6. Uveitis was… CONTINUE READING
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