Interleukin-6-deficient mice develop mature-onset obesity

  title={Interleukin-6-deficient mice develop mature-onset obesity},
  author={V. Wallenius and K. Wallenius and B. Ahr{\'e}n and M. Rudling and H. Carlsten and S. Dickson and C. Ohlsson and John-Olov Jansson},
  journal={Nature Medicine},
  • V. Wallenius, K. Wallenius, +5 authors John-Olov Jansson
  • Published 2002
  • Biology, Medicine
  • Nature Medicine
  • The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6−/− mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement. The obese Il6−/− mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to… CONTINUE READING
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