Interleukin-6-deficient mice develop mature-onset obesity

@article{Wallenius2002Interleukin6deficientMD,
  title={Interleukin-6-deficient mice develop mature-onset obesity},
  author={Ville Wallenius and Kristina Wallenius and Bo Ahr{\'e}n and Mats Rudling and Hans Carlsten and Suzanne L Dickson and Claes Ohlsson and John-Olov Jansson},
  journal={Nature Medicine},
  year={2002},
  volume={8},
  pages={75-79}
}
The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6−/− mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement. The obese Il6−/− mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to… 
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La Interleucina 6 (IL-6) es una citocina altament multifuncional, amb moltes accions pleiotropiques, considerada una de les principals citocines controlant el sistema immune i coordinant-lo amb els
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