Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

@article{Matthews2010Interleukin6deficientMD,
  title={Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance},
  author={V. Matthews and T. Allen and S. Risis and M. S. Chan and D. Henstridge and N. Watson and L. A. Zaffino and J. R. Babb and J. Boon and P. Meikle and J. Jowett and M. Watt and J. O. Jansson and C. Bruce and M. Febbraio},
  journal={Diabetologia},
  year={2010},
  volume={53},
  pages={2431-2441}
}
  • V. Matthews, T. Allen, +12 authors M. Febbraio
  • Published 2010
  • Biology, Medicine
  • Diabetologia
  • Aims/hypothesisThe role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6−/−) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance.MethodsMale, 8-week-old Il6−/− and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly.ResultsIl6−/− mice displayed… CONTINUE READING
    251 Citations
    Adipocyte specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice.
    • 3
    • PDF
    Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice.
    • 30
    • Highly Influenced
    Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse.
    • 6
    Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice
    • 22
    • PDF
    Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL‐6 production
    • 7
    • PDF
    Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice.
    • 32
    • PDF
    Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice
    • 27
    • PDF
    Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice
    • 54
    • PDF
    Interleukin-6 deficiency facilitates myocardial dysfunction during high fat diet-induced obesity by promoting lipotoxicity and inflammation.
    • F. Chen, D. Chen, +9 authors Junmei Ye
    • Biology, Medicine
    • Biochimica et biophysica acta. Molecular basis of disease
    • 2017
    • 17

    References

    SHOWING 1-10 OF 52 REFERENCES
    Interleukin-6 depletion selectively improves hepatic insulin action in obesity.
    • 261
    • PDF
    Human IL6 enhances leptin action in mice
    • 125
    • Highly Influential
    • PDF
    Interleukin-6-deficient mice develop mature-onset obesity
    • 1,092
    Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • 1,805
    Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity.
    • 158
    • Highly Influential
    • PDF
    Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice.
    • 453
    • PDF
    Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.
    • 916
    Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
    • 158
    • PDF
    Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice
    • 148
    • PDF
    The role of interleukins in insulin resistance and type 2 diabetes mellitus
    • 212