Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

  title={Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance},
  author={V. Matthews and T. Allen and S. Risis and M. S. Chan and D. Henstridge and N. Watson and L. A. Zaffino and J. R. Babb and J. Boon and P. Meikle and J. Jowett and M. Watt and J. O. Jansson and C. Bruce and M. Febbraio},
  • V. Matthews, T. Allen, +12 authors M. Febbraio
  • Published 2010
  • Biology, Medicine
  • Diabetologia
  • Aims/hypothesisThe role of IL-6 in the development of obesity and hepatic insulin resistance is unclear and still the subject of controversy. We aimed to determine whether global deletion of Il6 in mice (Il6−/−) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, inflammation and insulin resistance.MethodsMale, 8-week-old Il6−/− and littermate control mice were fed a standard chow or HFD for 12 weeks and phenotyped accordingly.ResultsIl6−/− mice displayed… CONTINUE READING
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