Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.

@article{Kobayashi2005Interleukin6CT,
  title={Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells.},
  author={Shogo Kobayashi and Nathan W. Werneburg and Steven F. Bronk and Scott H. Kaufmann and Gregory J. Gores},
  journal={Gastroenterology},
  year={2005},
  volume={128 7},
  pages={2054-65}
}
BACKGROUND & AIMS Cholangiocarcinomas often arise within a background of chronic inflammation suggesting that inflammation imparts survival signals to this cancer. Previous studies have also shown that the inflammatory cytokine interleukin (interleukin [IL]-6) contributes to survival signals in an autocrine fashion and that myeloid cell leukemia-1 (Mcl-1), an antiapoptotic member of the B-cell leukemia-2 family, is an important participant in tumor necrosis factor-related apoptosis-inducing… CONTINUE READING
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