Interleukin-6 concentrations in neonates evaluated for sepsis.

@article{Doellner1998Interleukin6CI,
  title={Interleukin-6 concentrations in neonates evaluated for sepsis.},
  author={H Doellner and K J Arntzen and P E Haereid and S Aag and Rigmor Austgulen},
  journal={The Journal of pediatrics},
  year={1998},
  volume={132 2},
  pages={
          295-9
        }
}

Serial interleukin 6 measurements in the early diagnosis of neonatal sepsis.

TLDR
It is concluded that an IL 6 value done at the time of presentation of signs and symptoms suggestive of infection is useful in the early diagnosis of neonatal sepsis and an initial IL6 value below 20 pg/ml may allow antibiotics to be withheld in a number of infants evaluated forSepsis.

Serum C-reactive protein and interleukin6 levels in neonatal sepsis.

TLDR
It is thought that serum CRP levels only which is a simple method may be used in the diagnosis of neonatal sepsis and WBC and serum IL-6 levels may be useful to establish mortality, because there was a statistically significant difference for these parameters between the survivors and deaths.

IMMEDIATE DIAGNOSIS OF EARLY ONSET SEPSIS IN PREMATURE NEWBORNS BY MEASUREMENT OF CORD C - REACTIVE PROTEIN AND INTERLEUKIN-6

TLDR
Having considered the relatively good sensitivity and moderate specificity of cord IL-6, this test can be recommended as a useful detector of early onset sepsis and non-infected sick neonates.

Serum Interleukin-6 Levels in Differential Diagnosis of Sepsis and Transient Tachypnea of Newborn

TLDR
The role of serum interleukin-6 levels in the differentiation of neonatal bacterial sepsis and TTN is evaluated and IL-6 alone can not distinguish TTN and sepsi.

Early Detection of Bacterial Sepsis in Newborns

TLDR
High IL-6 levels show some correlation with positive bacterial blood culture and it can help in supplementing the diagnosis of neonatal sepsis and it may be used to treat these cases especially in settings where blood culture facilities are remote.

Reduction of Unnecessary Antibiotic Therapy in Newborn Infants Using Interleukin-8 and C-Reactive Protein as Markers of Bacterial Infections

TLDR
The combination of IL-8 and/or CRP is a reliable and early test for the diagnosis of NBI in newborn infants and using the combination to restrict antibiotic therapy to truly infected infants reduces unnecessary antibiotic therapy and is cost-effective.

Diagnostic value of interleukin-6 and C-reactive protein on early onset bacterial infection in preterm neonates with respiratory distress

TLDR
The combination of IL-6 (0 h) and/or CRP (24 h) is helpful for excluding early onset infection in preterm infants with RD but the poor specificity limits its potential benefit as a diagnostic tool.

The Diagnostic Performance of Interleukin-6 and C-Reactive Protein for Early Identification of Neonatal Sepsis

TLDR
The recommendation is based on increased sensitivity, that is, to minimize the risk of any missing cases of sepsis, and the combination of IL-6 and CRP alone at cut-off 8.01 mg/L might be used to identify clinicalSepsis cases among culture negative sepsi suspected neonates in hospital settings.

Cord blood interleukin-6 as a predictor of early-onset sepsis in preterm babies

TLDR
Cord blood IL-6 can be used as a predictor of early-onset neonatal sepsis in preterm babies and is significantly higher in the septic group (probable and proven) than in the noninfected group.

α1-Acid glycoprotein for the early diagnosis of neonatal sepsis

TLDR
It is shown that CRP has limited value in the early diagnosis of neonatal sepsis and a significant increase in α1AG levels was detected in neonatalSepsis but its high specificity was accompanied with low sensitivity.
...

References

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INTERLEUKIN‐6: A SENSITIVE PARAMETER FOR THE EARLY DIAGNOSIS OF NEONATAL BACTERIAL INFECTION: 480

TLDR
Il-6 is a sensitive parameter for diagnosing neonatal bacterial infection and the combination of CRP and Il-6 seems to be the ideal tool for the early diagnosis of neonatal infection.

Early diagnosis of neonatal sepsis.

TLDR
To better define the need for antibiotic therapy, several tests recommended as helpful in diagnosing neonatal sepsis were evaluated and the combination of leukopenia and an elevated band/total neutrophil ratio seems to be particularly predictive of sepsi.

Increased plasma levels of interleukin-6 in sepsis [see comments]

TLDR
Levels of IL-6 on admission appeared to be of prognostic significance: levels were higher in septic patients who subsequently died than in those who survived, in particular when only patients with septic shock were considered.

Diagnostic value of plasma levels of tumor necrosis factor α (TNFα) and interleukin‐6 (IL‐6) in newborns with sepsis

TLDR
The combination of TNFα and IL‐6 determinations appears to be a good predictor of neonatal sepsis.

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome

TLDR
Data indicate that a complex pattern of cytokines exists in serum from patients with meningococcal septic shock, and that the release of IL-6 and IL-1, in addition to TNF-alpha, is associated with fatal outcome.

Defective production of interleukin-6 in very small premature infants in response to bacterial pathogens

TLDR
It was demonstrated that IL-6 responses to lipopolysaccharide stimulation were reduced in preterm newborns, implying some inherent abnormality of monocytes inPreterm babies, and may be partly responsible for the susceptibility of pre term newborn infants to bacterial infections.

The Capability of Neonatal Leukocytes to Produce IL-6 on Stimulation Assessed by Whole Blood Culture

TLDR
The results suggest that the production of IL-6 in response to specified stimuli is normal at birth, and immunocytochemical observations suggested that the major IL- 6 producing cells in the stimulated blood may be monocytes.