Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy.

@article{Sauty1996Interleukin6AT,
  title={Interleukin-6 and tumor necrosis factor alpha levels after bisphosphonates treatment in vitro and in patients with malignancy.},
  author={Alain Sauty and Martin Pecherstorfer and I. Zimmer-Roth and Pio Fioroni and Lucienne Juillerat and Matthew J. Markert and Hubertus Ludwig and Ph. Leuenberger and Paula L. Burckhardt and Daniel Louis Thiebaud},
  journal={Bone},
  year={1996},
  volume={18 2},
  pages={
          133-9
        }
}
Bisphosphonates are potent inhibitors of bone resorption and are widely used in the treatment of bone diseases. One of the side effects of administered aminobisphosphonates is transient fever and some biological changes that are suggestive of an acute phase response. Pamidronate [(3-amino-1-hydroxypropylidene).1, 1-bisphosphonate] and ibandronate [1-hydroxy-3-(methylpentylamino) propylidenebisphosphonate] incubated in heparinized whole blood at doses of 10(-4) and 10(-5) mol/L, induced the… CONTINUE READING
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