Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation.

@article{Kotake1996Interleukin6AS,
  title={Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation.},
  author={Shigeru Kotake and Kaori Sato and Kyungjae J Kim and Naoyuki Takahashi and Nobuyuki Udagawa and Ichiro Nakamura and Akira Yamaguchi and Tadamitsu Kishimoto and Tatsuo Suda and Sadao Kashiwazaki},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1996},
  volume={11 1},
  pages={88-95}
}
Chronic immune responses and inflammatory reactions in rheumatoid arthritis (RA) often cause severe destruction of cartilage and bone, but its mechanism is still a matter of controversy. We reported that interleukin-6 (IL-6) alone does not induce osteoclast formation, but soluble interleukin-6 receptors (sIL-6R) triggered the formation in the presence of IL-6 in cocultures of murine osteoblastic cells and bone marrow cells. In this study, we examined the involvement of sIL-6R and IL-6 in joint… CONTINUE READING

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