Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior.

  title={Interleukin-6 and leptin mediate lipopolysaccharide-induced fever and sickness behavior.},
  author={Lois May Harden and Irn{\'e} du Plessis and Stephen Poole and Helen P. Laburn},
  journal={Physiology & behavior},
  volume={89 2},
Pro-inflammatory cytokines, interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) synthesized by activated macrophages and monocytes in response to administration of lipopolysaccharide (LPS), are considered important mediators of fever and sickness behavior. We administered rat-specific antisera for TNF-alpha, IL-1beta, IL-6 and leptin, to determine the involvement of peripherally released cytokines in LPS-induced fever and sickness behavior, measured as suppression of… CONTINUE READING


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