Interleukin-6 and its receptor: from bench to bedside


Interleukin-6 (IL-6) is an inflammatory cytokine with a well-documented role in inflammation and cancer. The cytokine binds to a membrane bound IL-6 receptor (IL-6R) and this complex associates with two molecules of the signal transducing protein gp130 thereby initiating intracellular signaling. While gp130 is present on most if not all cells of the body… (More)
DOI: 10.1007/s00430-006-0019-9


6 Figures and Tables