Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis.

@article{Nasi2016Interleukin6AC,
  title={Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis.},
  author={Sergio Nasi and Alexander Kai Lik So and Christ{\`e}le Combes and Michel Daudon and Nathalie Busso},
  journal={Annals of the rheumatic diseases},
  year={2016},
  volume={75 7},
  pages={
          1372-9
        }
}
OBJECTIVES Basic calcium phosphate (BCP) crystal and interleukin 6 (IL-6) have been implicated in osteoarthritis (OA). We hypothesise that these two factors may be linked in a reciprocal amplification loop which leads to OA. METHODS Primary murine chondrocytes and human cartilage explants were incubated with hydroxyapatite (HA) crystals, a form of BCP, and the modulation of cytokines and matrix-degrading enzymes assayed. The ability of IL-6 to stimulate chondrocyte calcification was assessed… CONTINUE READING

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