Interleukin 6 and autoantibodies in juvenile rheumatoid arthritis.


OBJECTIVE To assess whether interleukin 6 (IL-6) may influence autoantibody production, the correlation of rheumatoid factors (RF) and antitype II collagen antibodies with IL-6 was determined in children with juvenile rheumatoid arthritis (JRA). METHODS IL-6 was measured by proliferation of the B-9 cell line or by ELISA: IgG, IgA, and IgM RF were measured… (More)