Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.

@article{Bauer1991Interleukin6AA,
  title={Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.},
  author={J{\"u}rgen Bauer and Sylvia Strauss and Ursula Schreiter-Gasser and U M Ganter and P O Schlegel and Irene Witt and B Yolk and Melvin Berger},
  journal={FEBS letters},
  year={1991},
  volume={285 1},
  pages={111-4}
}
Recent studies indicated that the formation of a major constituent of Alzheimer's disease (AD) senile plaques, called beta A4-peptide, does not result from normal processing of its precursor, amyloid precursor protein (APP). Since proteolytic cleavage of APP inside its beta A4 sequence was found to be part of APP processing the formation of the beta A4-peptide seems to be prevented under normal conditions. We considered whether in AD one of the endogenous proteinase inhibitors might interfere… CONTINUE READING
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