Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.

Abstract

BACKGROUND Ischemic preconditioning has been shown to protect the liver from ischemia/reperfusion injury. We hypothesized that IL-6 directly modulates the protective effects of ischemic preconditioning. METHODS Three weeks after undergoing splenic transposition, wild-type C57BL/6 and IL-6 null mice underwent 75 minutes of total hepatic ischemia with or… (More)

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Cite this paper

@article{Matsumoto2006Interleukin6AS, title={Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning.}, author={Tadashi Matsumoto and Kerri A. O'Malley and Philip Alexander Efron and Colette Burger and Priscilla F Mcauliffe and Philip O Scumpia and Takefumi Uchida and Sven Kevin Tschoeke and Shiro Fujita and Lyle L. Moldawer and Alan W. Hemming and David P. Foley}, journal={Surgery}, year={2006}, volume={140 5}, pages={793-802} }