Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

@inproceedings{PuzianowskaKunicka2016Interleukin6AC,
  title={Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study},
  author={M Puzianowska-Kuźnicka and Magdalena Owczarz and Katarzyna Wieczorowska-Tobis and Paweł Nadrowski and Jerzy Chudek and Przemyslaw Slusarczyk and Anna Skalska and Marta Izabela Jonas and Edward Franek and Malgorzata Mossakowska},
  booktitle={Immunity & Ageing},
  year={2016}
}
In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factors, interleukin-6 (IL-6) and C-reactive protein (CRP), were associated with physical and cognitive performance, and could predict mortality in successfully aging elderly. IL-6 and CRP levels systematically increased… CONTINUE READING

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Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
Using data from several thousand Eastern Europeans aged 65 years and older , we investigated whether the serum levels of two proinflammatory factors , interleukin-6 ( IL-6 ) and C - reactive protein ( CRP ) , were associated with physical and cognitive performance , and could predict mortality in successfully aging elderly . IL-6 and CRP levels systematically increased in an age - dependent manner in the entire study group ( IL-6 : n = 3496 individuals , p < 0.001 and CRP : n = 3632 , p = 0.003 ) , and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease , myocardial infarction , stroke , type 2 diabetes , or cancer , and had a Mini Mental State Examination ( MMSE ) score ≥24 and a Katz Activities of Daily Living ( ADL ) score ≥5 ( IL-6 : n = 1258 , p < 0.001 and CRP : n = 1312 , p < 0.001 ) .
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