Interleukin-6 Enhances Expression of Adenosine A1 Receptor mRNA and Signaling in Cultured Rat Cortical Astrocytes and Brain Slices

@article{Biber2001Interleukin6EE,
  title={Interleukin-6 Enhances Expression of Adenosine A1 Receptor mRNA and Signaling in Cultured Rat Cortical Astrocytes and Brain Slices},
  author={Knut Biber and Beate Lubrich and Bernd L. Fiebich and Hendrikus W. G. M. Boddeke and Dietrich van Calker},
  journal={Neuropsychopharmacology},
  year={2001},
  volume={24},
  pages={86-96}
}
The inhibitory neuromodulator adenosine is released in the brain in high concentrations under conditions of exaggerated neuronal activity such as ischemia and seizures, or electroconvulsive treatment. By inhibiting neural overactivity, adenosine counteracts seizure activity and promotes neuronal survival. Since stimulation of adenosine A2b receptors on… CONTINUE READING