Interleukin 6--a potential mediator of lethal sepsis after major thermal trauma: evidence for increased IL-6 production by peripheral blood mononuclear cells.

@article{Schlueter1991Interleukin6P,
  title={Interleukin 6--a potential mediator of lethal sepsis after major thermal trauma: evidence for increased IL-6 production by peripheral blood mononuclear cells.},
  author={Bernhard Schlueter and Brigitte Koenig and Ulrich Bergmann and Frank M{\"u}ller and W. K{\"o}nig},
  journal={The Journal of trauma},
  year={1991},
  volume={31 12},
  pages={1663-70}
}
We studied the plasma levels of the acute phase mediator interleukin 6 (IL-6) in 21 severely burned patients (burn injuries ranging from 24% to 75% total body surface area). The posttraumatic course of the IL-6 plasma levels was closely related to the clinical outcome. The nonseptic survivors as well as survivors with suspected sepsis (n = 14) exhibited maximal amounts of IL-6 (251 +/- 32 pg/mL) during the first 3 days post-burn, which subsequently returned to values within the normal range… CONTINUE READING

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