Interleukin-6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice.

@article{Galiano2001Interleukin6A,
  title={Interleukin-6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice.},
  author={Matthias Galiano and Zhi Qiang Liu and Roger Kalla and Marion Bohatschek and Andrea Koppius and Andreas Gschwendtner and Shiqin Xu and Alexander Werner and Christian U A Kloss and Leonard L. Jones and Horst Bluethmann and Gennadij Raivich},
  journal={The European journal of neuroscience},
  year={2001},
  volume={14 2},
  pages={327-41}
}
Nerve injury triggers numerous changes in the injured neurons and surrounding non-neuronal cells. Of particular interest are molecular signals that play a role in the overall orchestration of this multifaceted cellular response. Here we investigated the function of interleukin-6 (IL6), a multifunctional neurotrophin and cytokine rapidly expressed in the injured nervous system, using the facial axotomy model in IL6-deficient mice and wild-type controls. Transgenic deletion of IL6 caused a… CONTINUE READING