Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas.

@article{Miki1989Interleukin6F,
  title={Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas.},
  author={Sunao Miki and Masayuki Iwano and Yoshio Miki and Mayuko Yamamoto and Betty K. P. Tang and Koji Yokokawa and Takanori Sonoda and Toshio Hirano and Tadamitsu Kishimoto},
  journal={FEBS letters},
  year={1989},
  volume={250 2},
  pages={607-10}
}
Interleukin-6 (IL-6) was found to be a growth factor of renal cell carcinomas Furthermore, renal cell carcinomas freshly isolated from the patients expressed mRNA of IL-6 and secreted biologically active IL-6 under the culture conditions where the tumor cells could grow, but they did not produce IL-6 nor proliferate in the absence of fetal calf serum. The production of IL-6 by the tumor cells was also demonstrated by immunostaining of the IL-6-producing cells utilizing anti-IL-6 antiserum… CONTINUE READING