Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus.

@article{Cash2010Interleukin6,
  title={Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus.},
  author={Hannes Cash and Manfred Relle and Julia Menke and Christoph Brochhausen and Simon A Jones and Nicholas Topley and Peter R. Galle and Andreas Schwarting},
  journal={The Journal of rheumatology},
  year={2010},
  volume={37 1},
  pages={60-70}
}
OBJECTIVE To investigate the pathophysiological effect of interleukin 6 (IL-6) on lupus nephritis in MRL-Fas(lpr) mice. METHODS We generated IL-6-deficient MRL-Fas(lpr) mice using a backcross/intercross breeding scheme. Renal pathology was evaluated using immunohistochemistry detection for macrophages, lymphocytes, vascular cell adhesion molecule-1 (VCAM-1), and TUNEL (terminal deoxynucleotide transferase-mediated dUTP nick end-labeling) for apoptotic cells, and renal IgG and C3 deposition by… CONTINUE READING
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  • HY Chun, JW Chung, HA Kim, JM Yun, JY Jeon, YM Ye
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