Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms.

  title={Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms.},
  author={Keith G Jones and David J. Brull and Leonard C Brown and Minder Sian and Roger M. Greenhalgh and Steve E Humphries and Janet T. Powell},
  volume={103 18},
BACKGROUND Abdominal aortic aneurysm is a multifactorial disorder in which inflammation is an important pathophysiological feature. In explant culture, aneurysm biopsies secrete large amounts of interleukin-6 (IL-6), and among aneurysm patients, the circulating concentration of IL-6 appears to be increased. METHODS AND RESULTS We investigated, in 19 patients, whether aneurysm wall was an important source of circulating IL-6. We also tested the hypotheses, in 466 patients with a small aneurysm… CONTINUE READING
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