Interleukin-6: effects on and production by rat granulosa cells in vitro.

@article{Gorospe1992Interleukin6EO,
  title={Interleukin-6: effects on and production by rat granulosa cells in vitro.},
  author={William C. Gorospe and Francis M Hughes and Bryan L. Spangelo},
  journal={Endocrinology},
  year={1992},
  volume={130 3},
  pages={1750-2}
}
Treatment of FSH-stimulated granulosa cells with increasing amounts of interleukin-6 (IL-6) caused a significant concentration-dependent suppression of progesterone biosynthesis. However, basal progesterone production in non-FSH-stimulated cells remained unresponsive to the cytokine. Quantitation of IL-6 in the conditioned media from untreated granulosa cells by the 7TD1 hybridoma cell bioassay revealed detectable levels of IL-6. Further, FSH treatment caused a significant concentration… CONTINUE READING

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