Interleukin-6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process.

@article{Liu2009Interleukin6AA,
  title={Interleukin-6: an autocrine regulator of the mouse cumulus cell-oocyte complex expansion process.},
  author={Zhilin Liu and Daniel G de Matos and Heng-Yu Fan and Masayuki Shimada and Stephen Palmer and Joanne S Richards},
  journal={Endocrinology},
  year={2009},
  volume={150 7},
  pages={3360-8}
}
Ovulation has long been regarded as a process resembling an inflammatory response. Recent studies indicate that genes associated with innate immune responses were also expressed during the ovulation process. Because the innate immune genes are induced in cumulus cell oocyte complexes (COCs) later than the inflammation-associated genes, we hypothesize that COC expansion is dependent on specific sequential changes in cumulus cells. Because IL-6 is a potent mediator of immune responses, we sought… CONTINUE READING

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