Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities.

@article{Eddahri2009Interleukin6STAT3SR,
  title={Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities.},
  author={Fouad Eddahri and S{\'e}bastien Denanglaire and Fabrice Bureau and Rosanne Spolski and Warren J Leonard and Oberdan Leo and Fabienne Andris},
  journal={Blood},
  year={2009},
  volume={113 11},
  pages={2426-33}
}
The conditions leading to the activation/differentiation of T-helper (Th) cells dedicated for B-cell antibody production are still poorly characterized. We now demonstrate that interleukin-6 (IL-6) promotes the differentiation of naive T lymphocytes into helper cells able to promote B-cell activation and antibody secretion. IL-6-driven acquisition of B-cell help capacity requires expression of the signal transducer and activator of transcription 3 (STAT3), but not STAT4 or STAT6 transcription… CONTINUE READING
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