Interleukin-6, its role in fibrosing conditions.

  title={Interleukin-6, its role in fibrosing conditions.},
  author={Steven O'Reilly and Marzena Ciechomska and Rachel Cant and Thomas H{\"u}gle and Jacob M van Laar},
  journal={Cytokine & growth factor reviews},
  volume={23 3},
Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune response. It is secreted by a wide array of cell types, however, its target cells are more restricted, due to the fact that very few cells, except lymphocytes and hepatocytes, express the functional membrane IL-6 receptor. This therefore limits the amount of cells that can respond to IL-6. Transsignalling, the shedding of the membrane bound form of the IL-6 receptor (sIL-6R) into the local microenvironment… CONTINUE READING