Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite.

@article{Goff2000Interleukin5IE,
  title={Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite.},
  author={Laetitia Le Goff and P. F. Loke and Hamdi F. Ali and Diane Wallace Taylor and Judith E Allen},
  journal={Infection and immunity},
  year={2000},
  volume={68 5},
  pages={2513-7}
}
The study of protective immune mechanisms effective against filarial nematodes has been hampered by the inability of these important human pathogens to infect laboratory mice. Recently, Litomosoides sigmodontis, a natural parasite of rats, has been developed as a valuable model for the study of filarial infection. BALB/c mice are fully susceptible to infection with L. sigmodontis third-stage larvae and develop patent infection. In contrast, mice on the C57BL background are resistant, and… CONTINUE READING