Interleukin-5 binds to heparin/heparan sulfate. A model for an interaction with extracellular matrix.

  title={Interleukin-5 binds to heparin/heparan sulfate. A model for an interaction with extracellular matrix.},
  author={Richard Lipscombe and A M Nakhoul and Colin J Sanderson and Deirdre R. Coombe},
  journal={Journal of leukocyte biology},
  volume={63 3},
Interleukin-5 (IL-5) is the major cytokine regulating eosinophil production. In allergic disease tissue damage is primarily caused by eosinophils. Heparan sulfate proteoglycans are components of the bone marrow stroma, which supports hemopoietic cell differentiation and proliferation. We show that at low IL-5 concentrations heparan sulfate enhances the proliferation of an IL-5-dependent cell line. To investigate a mechanism for this effect we used an artificial proteoglycan to establish an… CONTINUE READING
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