Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.

@article{Lopez1991Interleukin5IA,
  title={Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils.},
  author={Angel F Lopez and Mathew A. Vadas and Joanna M Woodcock and Sterling Milton and Alaron Lewis and Michael J. Elliott and David Gillis and Robert E. Ireland and E Olwell and Linda S. Park},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 36},
  pages={24741-7}
}
Human interleukin (IL)-5 receptors were characterized by means of binding studies using bioactive 125I-labeled IL-5. Of purified primary myeloid cells, eosinophils and basophils but not neutrophils or monocytes expressed surface receptors for IL-5. Binding studies showed that eosinophils expressed a single class of high affinity receptors (Ka = 1.2 x 10(10) M-1) with the number of receptors being small (less than 1000 receptors/cell) and varying between individuals. Among several cell lines… CONTINUE READING
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