Interleukin 4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells.

@article{Akashi1991Interleukin4S,
  title={Interleukin 4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells.},
  author={Koichi Akashi and T Tsunefumi Shibuya and M. D. N. Harada and Yasushi Takamatsu and Naokuni Uike and Tetsuya Eto and Yoshiyuki Niho},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={88 1},
  pages={223-30}
}
We studied the effects of IL-4 on the spontaneous proliferation of chronic myelomonocytic leukemia (CMMoL) cells in vitro. IL-4 (100 U/ml) suppressed the spontaneous DNA synthesis by approximately 50% in 5 of 8 cases examined. IL-4 (100 U/ml) also inhibited the spontaneous colony formation by CMMoL cells in a methylcellulose culture by 50-97% in all of the 10 cases in which spontaneous colonies were formed. This IL-4-mediated suppression of the growth of CMMoL cells was completely abolished by… CONTINUE READING

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