Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages.

@article{Zhou1994Interleukin4SI,
  title={Interleukin-4 suppresses inflammatory cytokine gene transcription in porcine macrophages.},
  author={Yue Zhou and Gang Lin and Mary J Baarsch and R W Scamurra and Michael Murtaugh},
  journal={Journal of leukocyte biology},
  year={1994},
  volume={56 4},
  pages={507-13}
}
Inflammatory cytokines, including interleukin (IL)-1 alpha, IL-1 beta, IL-8, and tumor necrosis factor alpha (TNF-alpha) are produced by macrophages in response to a variety of pathogenic stimuli. We show here that the expression of inflammatory cytokines is suppressed by IL-4 at the transcriptional level. Interleukin-4, when added together with bacterial lipopolysaccharide (LPS), suppressed LPS-induced increases in mRNA levels of IL-1 alpha, IL-1 beta, IL-8, and TNF-alpha in alveolar… CONTINUE READING

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