Interleukin 4 receptors on normal human B lymphocytes: characterization and regulation.

@article{Zuber1990Interleukin4R,
  title={Interleukin 4 receptors on normal human B lymphocytes: characterization and regulation.},
  author={C E Zuber and Jean Pierre Galizzi and Alfredo del Valle and Nagakatsu Harada and Maureen Howard and Jacques Banchereau},
  journal={European journal of immunology},
  year={1990},
  volume={20 3},
  pages={551-5}
}
Human interleukin 4 (IL 4) up-regulates the expression of CD23 on both resting and "in vivo" activated B cells but induces proliferation and/or differentiation only on "in vitro" activated B lymphocytes. Resting B cells express 360 high-affinity IL 4 receptors (R) per cell (Kd = 25-75 pM). Activation of resting B cells with anti-IgM antibody or Staphylococcus aureus Cowan I (SAC) results in a two-to-threefold increase of IL 4R number without alteration of IL 4R affinity for IL 4. Flow… CONTINUE READING