Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection.

@article{Mohrs2000Interleukin4RA,
  title={Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection.},
  author={Markus Mohrs and Christoph Holscher and Frank Brombacher},
  journal={Infection and immunity},
  year={2000},
  volume={68 4},
  pages={1773-80}
}
We recently generated interleukin-4 (IL-4) receptor alpha-deficient (IL-4Ralpha(-/-)) BALB/c mice and showed evidence for a protective role of IL-13-mediated functions in leishmaniasis. In this study, we investigated the IL-4 expression and T helper 2 (Th2) development in Leishmania major-infected IL-4Ralpha(-/-) mice. Here we show that the early burst of IL-4 expression observed in L. major-infected BALB/c mice is independent of IL-4Ralpha-mediated functions. Subsequently, we confirmed an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

Similar Papers

Loading similar papers…